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• Title: Study of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques
• Author : Hareesha Reddy Venumuddala
• Release Date : January 19, 2013
• Genre: Medical,Books,Professional & Technical,
• Pages : * pages
• Size : 7969 KB

Description

This Master of Science thesis encompasses two projects in chemical pharmaceuticals. The first is a study of excipients and the added new information collected beyond Thermal Gravimetric Analysis and Differential Scanning Calorimetry from Dielectric Analysis. These new properties enhance our global knowledge of excipients by thermal analytical methods. Excipients, the inactive ingredients in formulated drugs, aid different functions of the active pharmacy ingredient, thedrugs. Low temperature transitions, by DEA including melting of frozen solvents, e.g. water, are more definitive than observed by low temperature DSC.Millions of dollars are expended annually on pharmaceutical testing to qualify excipients for fully formulated drugs, medicines and active ingredients. To understand the action of the excipients in the human body at body temperature of 37°C, the study of their individual and interactive properties are desirable. DEA DSC and Thermal Gravimetric analysis (TGA) methods are employed to screen the most widely used drug excipients. In this study the following excipients were examined by DEA: cotton seed oil, mannitol, peanut oil, polyethylene glycol, sugar, sodium lauryl sulfate, sodium starch glycolate, sodium stearate, canola oil, and anhydrous lactose, benzoic acid and vanillin. The comparison of DSC and DEA thermal curves for each excipient indicates that major endothermic events have occurred e.g., volatilization or melting of the excipient are viewed as fundamental DEA properties. These properties are the rise in permittivity and dielectric loss factor. The focus of this project was to learn to prepare, examine and interpret the resulting variations.The electrical conductivity (e” * frequency* constant), permittivity (e’) and tan delta value (e”/e’) are used to enhance the characterization of the excipient.The second, and major project for this thesis, is to evaluate bipolar disorder drug transport with and without an applied electric field of 10V mm-1. Drug delivery was tested with several animal models, dry shed snake skins and a moist pig skin, which will be used to develop a new transdermal patch. Characterization of appropriate drugs by DEA and other thermal analytical methods will aid the understanding of chemical stability and interactions .These properties will aid a Bipolar Disorder (BPD) patient to receive their correct dosage in a timely manner and improve patient compliance. BPD also called as Manic Depressive Disorder results in extreme shifts in mood and behavior that may last for weeks or months, causing severe disturbances in the lives of those affected. A high percentage of BPD is untreated due to the lack of a well-tolerated and effective drug transport therapy. So, the analysis of the selected drugs by thermal analytical techniques gives support to understand the transport properties. Studying the transport properties of these drugs through a transdermal route may pave the way for a novel transdermal drug delivery method. In this study, Dielectric Analysis (DEA) is used to characterize and evaluate the transport properties of the selected drugs (Olanzapine, Risperidone, and Quetiapine Fumarate). Dielectric Analysis implements drug delivery employing an AC frequency, modulating drugs of a wide molecular weight range (e.g. 300 to 30,000 Daltons) with an interdigitated electrode system. In this analysis, thedrugs were studied using animal models (Shed snake skin and pig skin). There is a specific frequency we discovered for each drug, where the change in the electric profile begins which “aids the delivery”. The delivery is measured by enhanced conductivity and is paralleled with increased drug throughput tracked by UV analysis.

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